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Estimation of a protein MMP-9 in pulpal blood of decayed teeth to find out the success of a conservative treatment option called Vital Pulp therapy for treatment of decayed painful tooth

Estimation of Matrix Metalloproteinase- 9 (MMP-9) in dental pulpal blood as a biomarker to predict the outcome of Vital Pulp Therapy in permanent mature teeth diagnosed with Symptomatic Irreversible Pulpitis. - nil

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/07/070778
Enrollment
150
Registered
2024-07-18
Start date
Unknown
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: NIL: NIL

Sponsors

Dr Mridula Parameswaran
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Healthy patient greater than or equal to 13 years of age Mature permanent teeth diagnosed with symptomatic irreversible pulpitis as per AAE Criteria Peri Apical Index score of 1 Positive response to cold and electric pulp tests Spontaneous or nocturnal or referred and or or lingering pain Teeth with restorable carious lesions

Exclusion criteria

Exclusion criteria: Immature roots or cracks or cusp fractures or subgingival caries. Poor periodontal health History of sinus tract or swelling Not willing to participate

Design outcomes

Primary

MeasureTime frame
Success or Failure of Vital pulpotomy in symptomatic irreversible pupitisTimepoint: Outcome shall be evaluated at 3rd 6th and 12 th month following pulpotomy—

Secondary

MeasureTime frame
To assess the difference in the level of MMP-9 in radicular dental pulpal blood of normal teeth and teeth with Symptomatic irreversible pulpitis. To find out any association between MMP-9 level in radicular dental pulpal blood and preoperative NSAID intake in patients with Symptomatic irreversible pulpitis Timepoint: shall be assessed at the end of 12 months—

Countries

India

Contacts

Public ContactDr Mridula Parameswaran

Government Dental college Thiruvananthapuram

mridulatdc@gmail.com09447450482

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026