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Efficacy of Carbetocin vs Oxytocin for the prevention of postpartum hemorrhage in high risk cases

Efficacy of carbetocin vs oxytocin for the prevention of post-partum haemorrhage in high risk cases:A randomized controlled trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/07/070664
Enrollment
486
Registered
2024-07-16
Start date
Unknown
Completion date
Unknown
Last updated
2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O721- Other immediate postpartum hemorrhage

Interventions

Intervention1: Carbetocin: Dose -100 mcg carbetocin in 10 ml Normal saline injected intravenously over 1-2 minutes - after birth of the baby - single dose along with active management as per WHO Contr

Sponsors

DrBhat Janvi Santosh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All pregnant females with any 1 and/or - 1)Anemia (Hb 2)Past history of PPH 3)Polyhydramnnios 4)Multiple pregnancy 5)Two or more Previous C-section 6)Presence of uterine fibroids 7)Previous myomectomy 8)Presence of APH 9)PRecipitate labour 10)Fetal macrosomia

Exclusion criteria

Exclusion criteria: 1)Women with history of Hypersensitivity to oxytocin 2)Cardiac,Renal or Liver diseases 3)Epilepsy , General anesthesia 4)Preeclampsia,Hypertension

Design outcomes

Primary

MeasureTime frame
To assess the need for additional uterotonicsTimepoint: Immediately after delivery of placenta -After 2 minutes -After 4 minutes -After 10 minutes -Immediate post op/post delivery period -After 2 hours of delivery -24 hours after delivery

Secondary

MeasureTime frame
To assess the amount of blood loss TO compare the hemodynamic effects(effects of Blood pressure and diuresis) To assess the adverse effects ienausea,vomitingTimepoint: -Immediately after delivery of placenta -After 2 minutes -After 4 minutes -Immediate post op/post delivery period -After 2 hours of delivery -24 hours after delivery

Countries

India

Contacts

Public ContactDr Bhat Janvi Santosh

Kalinga Institute of Medical Sciences , Bhubaneshwar

drasimadas@gmail.com9437316299

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026