To compare the levels of Creatinine and Alkaline Phosphatase in blood in patients suffering from Chronic gum disease with and without Type 2 Diabetes Mellitus Before and After Scaling and Root Planing.

Comparative Evaluation of Serum Creatinine and Alkaline Phosphatase levels in Chronic Periodontitis Patients with and without Type 2 Diabetes Mellitus Before and After Scaling and Root Planing- A Clinico-biochemical Study - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/070634

Enrollment

Registered

2024-07-15

Start date

Unknown

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K051- Chronic gingivitis Health Condition 2: E119- Type 2 diabetes mellitus without complications

Interventions

Intervention1: Scaling and Root planing: Scaling and Root planing in chronic periodontitis patients Duration for this will be 6 months Control Intervention1: Serum creatinine and alkaline phosphatase:

Eligibility

Inclusion criteria

Inclusion criteria: Group A: Periodontally healthy patients with no clinical gingival inflammation and GI equal to 0, probing depth (PPD) less than or equal to 3 mm, and no radiographic evidence of bone loss Group B: Chronic periodontitis patients without T2DM with GI greater than 1, PPD greater than or equal to 6mm and CAL greater than or equal to 5mm. Group C: Chronic periodontitis patients with T2DM patients, GI greater than 1, PPD greater than or equal to 6mm and CAL greater than 5mm. HbA1c levels between 5-7%.

Exclusion criteria

Exclusion criteria: 1. Patients who have undergone any periodontal therapy in the past 6 months. 2. Patients with symptoms of acute illness. 3. Patients who are on immunosuppressive therapy or having any other systemic illness. 4 Systemic anti-inflammatory treatment within the previous 3 months or regular use of specific drugs known to affect periodontal tissues. 5. Pregnant women and lactating mothers.

Design outcomes

Primary

Measure	Time frame
BIOCHEMICAL PARAMETERS 1) Fasting plasma glucose (FPG) 2) Post Prandial plasma glucose (PPG) 3) HbA1c 4) Creatinine 5) Alkaline phosphatase CLINICAL PARAMETERS 1.Plaque Index (P.I.) (Tureskey-Gilmore-Glickman Modification of Quigley Hein) 2.Gingival Index (G.I.) (Loe and Silness, 1963) 3.Probing Pocket Depth (PPD) 4.Clinical Attachment Level (CAL) Timepoint: At baseline and after 4 weeks	—

Secondary

Measure	Time frame
serum Alkaline phosphatase and serum creatinine levels in normal people and in people suffering from type 2 diabetes mellitusTimepoint: serum Alkaline phosphatase and serum creatinine levels before scaling and root planing and 4 weeks post scaling and root planing	—

Countries

India

Contacts

Public ContactDr Praneeta Kamble

Nair hospital Dental College, Mumbai

drpraneetakamble@gmail.com9820263468

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026