Effect of Dexmedetomidine and Sevoflurane on the quality of recovery and cognitive function after general anaesthesia

Comparison of Dexmedetomidine and Sevoflurane on the quality of recovery and cognitive function after general anaesthesia: A Randomised Single Blinded clinical trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/070550

Enrollment

Registered

2024-07-13

Start date

Unknown

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K87- Disorders of gallbladder, biliarytract and pancreas in diseases classified elsewhere Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Dexmedetomidine and Sevoflurane as General anaesthesia: Group (S) Patients will receive general anaesthesia using sevoflurane (0.6-1.5) % dial concentration adjusted to maintain a BIS o

Eligibility

Inclusion criteria

Inclusion criteria: 1.Adult subjects classified as American Society of Anaesthesiologists (ASA) I-II.2.Non-obese individuals with a body mass index (BMI) below 30kg/m2.3.Mini-Mental State Examination(MMSE) score 25 preoperatively.4.Patients undergoing general anaesthesia of more than 2 hours and less than 6 hours at UPUMS hospital.

Exclusion criteria

Exclusion criteria: 1.Patient refusal. 2.Presence of health conditions(e.g.cardiac, pregnancy, pulmonary diseases,neurological condition) 3.Visual/hearing impairment, smoking/alcohol abuse, cognitive dysfunction. 4.Mini-Mental State Examination (MMSE) score less than 25 preoperatively. 5.Any known allergy to drugs.

Design outcomes

Primary

Measure	Time frame
Comparison of Dexmedetomidine and Sevoflurane on QoR-15(Quality of recovery questionnaire)Timepoint: Preoperatively (30 min before surgery) Post-operative Day-1 Post-operative Day -2 At the day of discharge	—

Secondary

Measure	Time frame
1.Comparison of Dexmedetomidine and Sevoflurane on MMSE(Mini mental state examination) 2.Comparison of hemodynamic parameters 3.Comparison of emergence agitation 4.comparison of side effect and any complicationsTimepoint: 1.Post-operative Day-1 2.Intraoperatively 3.After two minutes after extubation 4.Intra-operative and Post-operative	—

Countries

India

Contacts

Public ContactDr Mamta Kushwaha

UTTAR PRADESH UNIVERSITY OF MEDICAL SCIENCES

ushashukla1970@gmail.com9412201915

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026