Health Condition 1: L408- Other psoriasis
Conditions
Interventions
Intervention1: oral methotrexate (according to body weight): Participants in this group will receive oral methotrexate, dosed according to standard clinical guidelines ( firstly test dose of 2.5mg is
Sponsors
KIRTI NITIN HAJARE
Eligibility
Inclusion criteria
Inclusion criteria: 1)Adult aged more than 18 years and less than 60 years 2)Confirmed case of palmoplantar psoriasis by skin punch biopsy. 3)History of palmoplantar psoriasis for atleast 6 months. 4)Both male and female.
Exclusion criteria
Exclusion criteria: 1)Age less than 18years and more than 60 years. 2)Patient with nail psoriasis and psoriatic arthropathy. 3)Patient unwilling to give consent. 4)Patient with anemia and infections GI disease, respiratory diseases. 5)Patient planning to have children. 6)history of recent live vaccination 7)Patient with co-morbidities. 8)Alcohol consumption, tobacco and smoking. 9)Organ transplant. 10)Patient with thromboembolism, stroke, cardiovascular disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint will be the improvement in the Modified Palmoplantar Psoriasis Area and Severity Index (mPPPASI) score specifically for the palmoplantar regions, from baseline to the end of the treatment period.Timepoint: baseline,2weeks,4weeks,8weeks,12weeks, follow up period of 3 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints will include patient-reported outcomes on pain and discomfort, quality of life measures, and a comprehensive safety profile assessment including laboratory monitoring for potential drug-related adverse effects.Timepoint: baseline,2weeks,4weeks,8weeks,12weeks, follow up period of 3 months | — |
Countries
India
Contacts
Public ContactKIRTI NITIN HAJARE
SHRI BHAUSAHEB HIRE GOVERNMENT MEDICAL COLLEGE,DHULE
Outcome results
None listed