Health Condition 1: O021- Missed abortion
Conditions
Interventions
Intervention1: letrozole pretreatment: patients in the letrozole group will get 10 mg of letrozole orally three days in a row, followed by 800 mg of misoprostol given sublingually on the morning of th
Sponsors
AIIMS Patna
Eligibility
Inclusion criteria
Inclusion criteria: (1) women aged 18-45 years at 6–12 complete weeks of gestation seeking medication abortion (2) having singleton pregnancy (3) agreeing to participate in the trial voluntarily (4) having no contraindications to medical abortion.
Exclusion criteria
Exclusion criteria: (1) incomplete, missed or inevitable miscarriage (defined by the clinical finding of an open cervix and bleeding) (2) suspected ectopic pregnancy, (3) history of heart, liver, kidney disease or adrenal insufficiency, (4) abnormal uterine lesions such as adenomyosis, fibroids or congenital malformations or intrauterine adhesion (5) pregnancy with an intrauterine contraceptive device in situ (6) history of coagulatory dysfunction or intake of anticoagulant drugs and
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| proportion of complete expulsion rate with mifepristone and letrozole Timepoint: immediately after intervention, at 7 days and 15 days | — |
Secondary
| Measure | Time frame |
|---|---|
| need for surgical evacuation Timepoint: at 15 days;time of expulsion of product of conception Timepoint: at 3 days and every 24 hours thereafter | — |
Countries
India
Contacts
Public ContactDR SUDWITA SINHA
AIIMS Patna
Outcome results
None listed