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To study the role of Transforming Growth Factor-ß in Oral precancerous lesions and Healthy Oral mucosa.

Molecular characterization of Transforming Growth Factor-ß in Low and High-Risk Oral Leukoplakia and Healthy Oral Mucosa-A Prospective Cross-Sectional Study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/07/070505
Enrollment
30
Registered
2024-07-12
Start date
Unknown
Completion date
Unknown
Last updated
2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K132- Leukoplakia and other disturbancesof oral epithelium, including tongue

Interventions

Intervention1: NIL: NIL

Sponsors

MGM Dental College and Hospital, Navi Mumbai
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Group I (control group): 1.Age and sex matched healthy oral leukoplakia cases. 2.Normal appearing mucosa of patients who will be undergoing crown lengthening; periodontal surgery and 3rd molar impaction surgery. Group II (study group): 1.Patients with low risk oral leukoplakia. 2.Patients with high- risk of oral leukoplakia

Exclusion criteria

Exclusion criteria: Group I (control group): 1.Patients not willing to participate. Group II (study group): 1.Patients with other established carcinomas. 2.Clinico histopathologically diagnosed OPMDS other than leukoplakia. 3.Patients who are undergoing any local / systemic treatment of oral leukoplakia 4.Patients not willing to participate in the study.

Design outcomes

Primary

MeasureTime frame
To evaluate and compare the m RNA expression of TGF- ß in low and high-risk oral leukoplakia and healthy oral mucosa by q PCR. Timepoint: Expected Timeline for the evaluation of the study 15 months.—

Secondary

MeasureTime frame
To evaluate & compare the immunoexpression of TGF- ß in low & high-risk oral leukoplakia & healthy oral mucosa.Timepoint: Expected Timeline for the evaluation of the study 15 months.—

Countries

India

Contacts

Public ContactDr Shilpa Patel

MGM Dental College and Hospital, Navi Mumbai

dr_shilpa0769@yahoo.com9987696594

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026