Vitamin C in gingival depigmentation

Comparative evaluation of ascorbic acid injections and topical gel application for management of gingival hypermelaninpigmentation patients. A randomized controlled study - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/070473

Enrollment

Registered

2024-07-11

Start date

Unknown

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K068- Other specified disorders of gingiva and edentulous alveolar ridge

Interventions

Intervention1: Vitamin C Mesotherapy: Vitamin C intramucosal injections to be injected locally for 3 times with 1 week interval Control Intervention1: Vitamin C gel: Vitamin C topical gel application

Eligibility

Inclusion criteria

Inclusion criteria: Subjects with age group: 18 - 40 years, both males and females. Individuals with untreated melanin pigmentation in the anterior portion of the upper or lower gingiva.

Exclusion criteria

Exclusion criteria: Patients who had previous depigmentation procedures. Patients with known hypersensitivity to ascorbic acid, under medication, systemic diseases, non-vital anterior teeth, active caries or who have undergone periodontal therapy in the past 6 months. Pregnant and lactating women, smokers and tobacco users.

Design outcomes

Primary

Measure	Time frame
Gingival pigmentation graded by the Dummett-Gupta Oral Pigmentation IndexTimepoint: Baseline, 3 months	—

Secondary

Measure	Time frame
Pain, satisfaction and cosmetic changes using Mc Gill pain and satisfactory questionnaireTimepoint: Baseline and 3 months	—

Countries

India

Contacts

Public ContactDr. G K CHETANA

Sri Rajiv Gandhi College of Dental Sciences and Hospital

umeshyadalam@gmail.com9844269511

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026