To assess the role of human placental extract in treating periodontitis

Effects of Professional Mechanical Plaque Removal and Human Placental Extract on Gingival Crevicular Fluid levels of Matrix Metalloproteinase-8 in Patients with Stage II Grade A/B Periodontitis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/070472

Enrollment

Registered

2024-07-11

Start date

Unknown

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Human Placental extract: Placentrex – the original research product of Albert David Limited, India, a drug obtained from fresh term healthy human placentae will be placed as a Local dru

Eligibility

Inclusion criteria

Inclusion criteria: 1.Age: 20-45 years 2.Presence of 20 or more natural teeth 3.Localised Stage I/II Grade A/B Periodontitis(AAP 2017) [Presence of localised Supra bony pocket of 4-6mm]

Exclusion criteria

Exclusion criteria: 1.Patients with Systemic illness 2.Patients with Molar/Incisor pattern Periodontitis 3.Pregnant and Lactating women 4.Patients using Smoking and Smokeless tobacco 5.Patient under local or systemic antibiotic or anti inflammatory therapy in past 3 months

Design outcomes

Primary

Measure	Time frame
Reduction in Probing Pocket Depth and Gain in Clinical attachment levelsTimepoint: Baseline and 2 Months	—

Secondary

Measure	Time frame
Improvement in Gingival index & Plaque Index scoresTimepoint: Baseline & 2 Months	—

Countries

India

Contacts

Public ContactTamil Selvan M D

Adhiparasakthi Dental College and Hospital

gnanasagar.perio@gmail.com9003209886

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026