Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Oral Melatonin Premedication: Oral Melatonin 6 mg will be administered as premedication on the day of surgery, 90 minutes before shifting to the operation theatre
Control Intervention1:
Sponsors
All India Institute of Medical Sciences, New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1. Written Consent 2. Supratentorial craniotomy for tumor less than 5 cm 3. ASA 1 and 2 4. Duration of surgery less than 4 hours and duration of anaesthesia less than 6 hours
Exclusion criteria
Exclusion criteria: 1. Patient’s refusal 2. Pregnancy 3. BMI more than 35 kg/m2 d. Patients who had sensitivity to the study drug e. Patients with deranged liver and renal functions f. American Society of Anaesthesiologists Class III and IV g. Previous history of craniotomy or any intracranial procedure h. Patients with altered sensorium i. Patients with midline shift of more than 5 mm on radiological imaging
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Preoperative anxiety score using the Amsterdam Preoperative Anxiety and Information Scale [APAIS]Timepoint: Baseline on the night before surgery and on the morning of surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Haemodynamics- Heart rate (beats per minute) and Mean arterial pressure (mmHg)Timepoint: Every 15 minutes intraoperatively;Regional cerebral oxygenation (rSO2)Timepoint: Every 15 minutes intraoperatively | — |
Countries
India
Contacts
Public ContactHemanshu Prabhakar
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed