Health Condition 1: B999- Unspecified infectious disease
Conditions
Interventions
Intervention1: Nil: Nil
Control Intervention1: Patients with Sepsis Without Autoimmune Diseases (Control Group): Inclusion Criteria:
1. Age 18 years and above.
2. Absence of documented autoimmune dise
Sponsors
Kasturba Hospital Manipal
Eligibility
Inclusion criteria
Inclusion criteria: 1. Confirmed diagnoses of autoimmune diseases based on established diagnostic criteria (e.g., ACR/EULAR classification criteria). 2. Clinical diagnosis of sepsis according to the Sepsis-3 criteria (SOFA score increase = 2 points due to infection) during hospitalisation.
Exclusion criteria
Exclusion criteria: 1. Age below 18 years 2. Lack of documented autoimmune disease diagnoses 3. Immunocompromised conditions not associated with autoimmune diseases (e.g., HIV/AIDS, solid organ transplantation) 4. Pregnancy, due to potential confounding effects on sepsis outcomes. 5. Inability to comprehend the study objectives or provide informed consent due to language or cognitive limitations 6. Limited availability for follow-up assessments or intended treatment, including discharge against medical advice
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sepsis Severity: Assess the severity of sepsis using the Sequential Organ Failure Assessment (SOFA) scoreTimepoint: Baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of Hospital Stay: Evaluate the duration of hospitalisation for sepsis patients with autoimmune diseases in comparision to those without autoimmune diseases.Timepoint: Baseline;Mortality: Determine the mortality rate among patients with autoimmune diseases & sepsis in comparision to those without autoimmune diseases.Timepoint: Baseline;Treatment Responses: Evaluate the influence of immunosuppressive therapies & biologic agents on the clinical trajectories of sepsis-related outcomes in patients with concurrent autoimmune diseases in comparison to those without autoimmune diseasesTimepoint: Baseline | — |
Countries
India
Contacts
Public ContactAdarsh
Kasturba medical college Manipal
Outcome results
None listed