Effects of nebulized dexmedetomidine versus nebulized magnesium sulphate on reducing intubation response

Comparison of hemodynamic effects of nebulized dexmedetomidine versus nebulized magnesium sulphate on attenuation of stress response during laryngoscopy and tracheal intubation- A randomized control trial - Not Applicable

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/070396

Enrollment

164

Registered

2024-07-10

Start date

Unknown

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H60-H95- Diseases of the ear and mastoid process

Interventions

Intervention1: Nebulized Dexmedetomidine: Nebulized dexmedetomidine 1mcg per kg over 15 minutes, 10minutes prior to induction and Hemodynamic responses to laryngoscopy is observed Control Intervention

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing elective surgery and belonging to ASA physical status I to II

Exclusion criteria

Exclusion criteria: Patients with difficult airway, uncontrolled hypertension, heart disease with ejection fraction less than 40%, body mass index more than 35 kg/m2, history suggestive of hypersensitivity to drugs used during the study, bradycardia- heart rate less than 50 beats per minute, any heart block, hepatic impairment, renal impairment and pregnancy.

Design outcomes

Primary

Measure	Time frame
To compare the hemodynamic effects of preoperative nebulized dexmedetomidine and nebulized magnesium sulphate on laryngoscopy and intubation stress response attenuationTimepoint: 1 hour	—

Secondary

Measure	Time frame
To assess the requirement of additional anesthetic drugs(fentanyl, propofol)in order to maintain the hemodynamics within 20% of baseline valuesTimepoint: 1 hour	—

Countries

India

Contacts

Public ContactBalaji Kuppuswamy

Christian Medical College

balooswamy@gmail.com7406777127

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026