Health Condition 1: A170- Tuberculous meningitis
Conditions
Interventions
Intervention1: Levofloxacin add on to the intensive phase of standard anti tubercular therapy: Add on oral levofloxacin in a dose of 10 mg/kg/day (once daily in children older than 5 years and in two
Sponsors
All India Institute of Medical Sciences, Rishikesh
Eligibility
Inclusion criteria
Inclusion criteria: Diagnosed cases of tubercular meningitis presenting to Department of Pediatrics, All India Institute Medical Sciences, Rishikesh with a diagnosis of TB meningitis as per Marais’ criteria and parents willing to comply with the study protocol and follow up
Exclusion criteria
Exclusion criteria: Pre-existing major chronic systemic illness including cardiovascular (arrhythmia, prolonged QTc interval or history of any arrhythmia), respiratory (chronic lung disease), gastrointestinal system (chronic liver disease) or chronic renal disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional Status ScaleTimepoint: 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Childhood Behavioural Checklist internalizing, externalizing and total scoreTimepoint: 12 weeks;Duration of hospitalisationTimepoint: At diagnosis;Functional status scaleTimepoint: 12 weeks;Number of patients with paradoxical reactionTimepoint: within 12 weeks;Pediatric Cerebral Performance CategoryTimepoint: 12 weeks;Social quotient by Vineland Social Maturity ScaleTimepoint: 12 weeks;SurvivalTimepoint: 12 weeks | — |
Countries
India
Contacts
Public ContactIndar Kumar Sharawat
All India Institute of Medical Sciences, Rishikesh
Outcome results
None listed