Health Condition 1: G049- Encephalitis, myelitis and encephalomyelitis, unspecified
Conditions
Interventions
Intervention1: Tab Minocycline: Add on oral minocycline through nasogastric tube for 7 days at a loading dose of 5 mg/kg/day followed by 2·5 mg/kg 12 hourly in children up to 12 years old and 200 mg l
Sponsors
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1.Children between age 1 month-18 years of age 2. Presenting to department of pediatrics, AIIMS Rishikesh with a clinical diagnosis of acute encephalitis syndrome 3. Parents willing to comply with the study protocol and follow up
Exclusion criteria
Exclusion criteria: 1. Preexisting major chronic systemic illness including cardiovascular, respiratory, gastrointestinal system or chronic renal disease 2. Preexisting developmental delay or intellectual disability 3. Definite diagnosis of neurometabolic or neurodegenerative disease 4. Caregivers not giving informed consent 5. History of allergy to minocycline previously 6. Children in whom Minocycline can’t be administered orally or through nasogastric tube within 72 hours of presenting to our institute due to clinical contraindications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is change in FSS scale score at 12 weeks as compared to baseline.Timepoint: baseline and 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| change in Glassgow coma scaleTimepoint: day0, day7 and 12 weeks;Change in Paediatric cerebral performance category scoreTimepoint: baseline day 7 and day 12;Childhood Behavioural ChecklistTimepoint: 12 weeks ;duration of hospitalisationTimepoint: 12 weeks ;mortalityTimepoint: day 7 and 12 weeks ;PedsQL scoreTimepoint: 12 weeks;Vineland adaptive behavior scoreTimepoint: 12 weeks ;Vineland social maturity scoreTimepoint: 12 weeks | — |
Countries
India
Contacts
Public ContactDr Indar Kumar Sharawat
All India institute of Medical Sciences, Rishikesh
Outcome results
None listed