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To compare sugammadex and neostigmine to acess hemodynamic response during the recovery of rocuronium in the brain surgery

Comparative study between sugammadex and neostigmine to evaluate hemodynamic response during reversal of rocuronium in patient undergoing craniotomy surgery: a randomised double blind controlled trial. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/07/070154
Enrollment
90
Registered
2024-07-08
Start date
Unknown
Completion date
Unknown
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: sugammadex reversal agent: patient received sugammadex 2mg/kg Control Intervention1: Neostigmine reversal agent: patient received neostigmine 50 microgram/kg plus glycopyrrolate 10 micr

Sponsors

DR KIRTI VERMA
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All pateints age group 18-65years with craniotomy surgeries and giving written informed consent. ASA GRADE 1 TO 3.

Exclusion criteria

Exclusion criteria: 1.Pateint refuse to participate. 2.Renal,Hepatic,Ventilatory Dysfunction. 3.Increased intracranial pressure. 4.Pregnancy or lactation. 5.Pateints with muscular dystrophies,myopathy,or cerebral palsy. 6.Pateints with a history of intolerance to any of the study drugs.

Design outcomes

Primary

MeasureTime frame
To compare the hemodynamic response Heart rate,SBP,DBP,MAP,SPO2 of sugammadex versus Neostigmine in reversal of rocuronium in pateints undergoing craniotomy surgery.Timepoint: 2min,5min,10min,15min,30min,60min,2hr,6hr,12hr,18hr,24hr.—

Secondary

MeasureTime frame
1.To evaluate the side effects (PONV) of sugammadex versus neostigmine in reversal of rocuronium in pateints undergoing craniotomy surgery. 2.To evaluate the Train of four Response of sugammadex versus neostigmine in reversal of rocuronium in pateints undergoing craniotomy surgery.Timepoint: 2min,5min,10min,15min,30min,60min,2hr,6hr,12hr,18hr,24hr.—

Countries

India

Contacts

Public ContactDR ARVIND KUMAR

INDIRA GANDHI INSTITUTE OF MEDICAL SCIENCES

kirti.kirtishalu@gmail.com7992256134

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026