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Relationship between levels of Interleukin-1a in gum fluid and the development of root resorption after dental injury.

Correlation Analysis of Interleukin-1a Levels in Gingival Crevicular Fluid with the Occurrence of External Root Resorption in Patients with Traumatic Dental Injury: A Prospective cohort Study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/07/070145
Enrollment
28
Registered
2024-07-08
Start date
Unknown
Completion date
Unknown
Last updated
2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K033- Pathological resorption of teeth

Interventions

Intervention1: NIL: NIL Control Intervention1: GCF collection in healthy tooth: Samples of GCF will be obtained by putting a paper strip into the gingival sulcus of each selected tooth until mild resi

Sponsors

nithiyalakshmi kanagaraj
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients of any gender, aged 14 –50 years, with a history of traumatic dental injury (Concussion / Subluxation / Extrusion / Intrusion/ Lateral luxation/ Avulsion) No evidence of caries or periodontal disease during intraoral examination or radiographic examination Systemically healthy patients with a non-contributory medical history

Exclusion criteria

Exclusion criteria: Patient with a history of Systemic inflammatory conditions or any chronic disease Patients who have taken systemic antibiotics or anti-inflammatory medications within one month prior to enrollment will be excluded. Patient with primary or secondary acute periodontitis Periodontal probing depth greater than 4mm

Design outcomes

Primary

MeasureTime frame
1. Correlation coefficient between IL-1a levels and occurrence, extent and progression of external root resorption (ERR) defect if any developed in patients with a history of traumatic dental injury. Timepoint: Baseline, 6 weeks, 3 months and 6 months—

Secondary

MeasureTime frame
1. Correlation between the type and severity of dental trauma and IL-1a levels in GCF and occurrence of ERR. 2. Calculation of sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) to assess the accuracy of IL-1a in GCF as a predictive biomarker for ERR development in patients with traumatic dental injury 3. Changes in IL-1a levels in gingival crevicular fluid (GCF) before and after the appropriate intervention for external root resorptionTimepoint: Baseline,6 weeks, 3 months and 6 months—

Countries

India

Contacts

Public ContactKNithiyalakshmi

Maulana Azad Institute of Dental Sciences

nithiyalakshmi1999@gmail.com9123514640

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026