Comparison of pain reducing effect of two local anesthetic drugs(Lidocaine versus Bupivacaine) when injected near the gallbladder(sub-serosal) during gallbladder stone surgery.

Effect of sub-serosal infiltration of Lidocaine versus Bupivacaine on post-operative pain in laparoscopic cholecystectomy at a tertiary care hospital in Sikkim- A randomized controlled clinical trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/070135

Enrollment

130

Registered

2024-07-07

Start date

Unknown

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Bupivacaine: A fine laparoscopic needle(20G) will be used to inject the 5 ml of 0.25% bupivacaine (preservative free) within the anterior serosa of Calots triangle after visually ascert

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing elective laparoscopic cholecystectomy.

Exclusion criteria

Exclusion criteria: 1. Any deviation from planned procedure 2. Jaundice 3. Gallbladder malignancy 3. Difficult cholecystectomy (Cushieri scale grade III, IV and Nassar scale grade 3, 4 and 5) 4. Subserosal infiltration deemed hazardous by operating surgeon. 5. Anaphylaxis. 6. Pregnancy

Design outcomes

Primary

Measure	Time frame
Post operative pain using visual analogue scale (VAS).Timepoint: At 1 hour, 4 hours, 12 hours and 24 hours.	—

Secondary

Measure	Time frame
1. Postoperative nausea and vomiting(PONV) 2. Pulse rate 3. Blood pressure.Timepoint: At 1 hour, 4 hours, 12 hours and 24 hours.	—

Countries

India

Contacts

Public ContactDr Varun Kumar Singh

Sikkim Manipal Institute of Medical Sciences

varunsingh.vks@gmail.com8787042291

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026