Health Condition 1: N858- Other specified noninflammatory disorders of uterus
Conditions
Interventions
Intervention1: Group A- Intravenous lignocaine group: Loading dose of intravenous lignocaine 2% (diluted to 0.25%)
1.5 mg/kg over 10 minutes before induction of anesthesia followed by an intravenous l
Sponsors
All India Institute of Medical Sciences Patna
Eligibility
Inclusion criteria
Inclusion criteria: Posted for total laparoscopic hysterectomy under general anesthesia American Society of anaesthesiology-physical status (ASA-PS) I and II.
Exclusion criteria
Exclusion criteria: 1. Allergy to local anaesthetics 2. BMI less than 18.5 kg/m2 and more than 30 kg/m2 3. Hepatic impairment 4. Renal impairment 5. any cardio-pulmonary diseases ( valvular heart disease, conduction block, myocardial depression, heart failure, etc ) 6. Seizure and neurological disorder 7. Breastfeeding female 8. Psychiatric disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess and compare perioperative pain outcome by administration of intraoperative intravenous lignocaine and placebo in patients undergoing total laparoscopic hysterectomy by perioperative opioid consumption till 24 hours postoperatively.Timepoint: till 24 hours postoperatively. | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess numerical rating score of painTimepoint: at 30 minutes, 2 hours, 6 hours, 24 hours;To assess plasma concentration of IL-6 before surgery and at 24 hours after surgeryTimepoint: before surgery and 24 hours after surgery;To assess the quality of recovery at 24 hours after surgeryTimepoint: at 24 hours;To know the incidence of postoperative nausea and vomitingTimepoint: at 24 hours | — |
Countries
India
Contacts
Public ContactDr Shagufta Naaz
AIIMS Patna
Outcome results
None listed