Health Condition 1: G00-G99- Diseases of the nervous system Health Condition 2: G231- Progressive supranuclear ophthalmoplegia [Steele-Richardson-Olszewski]
Conditions
Interventions
Intervention1: repetitive transcranial nerve stimulation: 2 sets of 5 daily sessions 1 month apart with coil positioned 3 cm lateral to inion , 1 cm inferior to lateral cerebellum.
20 trains of 10 bu
Sponsors
dr deepika Joshi
Eligibility
Inclusion criteria
Inclusion criteria: probable or possible PSP defined by MDS criteria ability to stand unassisted for 30 seconds and ability to walk independently with walker MMSE 18 or more on stable treatment of anticholinergic, dopaminergic , serotonergic sedative or NMDA receptor antagonist
Exclusion criteria
Exclusion criteria: history of cerebellar ataxia, subdural hematoma, space occupying lesion, hydrocephalus prior vestibular disease sensory deficit in feet epilepsy and psychotic disorder active intake of antiseizure medication pregnancy presence of electrically, magnetically active implants or metal exposures that preclude use of rTMS
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| to study efficacy in motor and nonmotor symptoms after cerebellar rTMS in progressive supranuclear palsy compared to sham procedure with parameters like PSP rating scale MDS non motor rating scale UPDRS part III PSP CDS MOCA FABTimepoint: patient will be assessed at the time of enrollment, at 1 month and at 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| to look for non motor and behavioral changes in patients with PSPTimepoint: patient will be assessed at the time of enrollment, at 1 month and at 6 months | — |
Countries
India
Contacts
Public ContactDr Deepika Joshi
IMS, BHU, varanasi
Outcome results
None listed