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To explore the prevalence, genetic and microbial profile of patients with aggressive nature of gum diseases

In-depth Exploration of the Prevalence, Genetic, and Microbiome Profile of Indian Population with Varying Severity of Periodontitis - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/07/069948
Enrollment
5000
Registered
2024-07-04
Start date
Unknown
Completion date
Unknown
Last updated
2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A488- Other specified bacterial diseases

Interventions

Intervention1: NIL: NIL Control Intervention1: NIL: NIL

Sponsors

Dr Aditi Chopra
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All participants between 10-80 years of age (both males and females) will be screened for the presence or absence of PD according to the 2017 classification of periodontal diseases (Caton et al., 2018, Papapanou et al., 2018). The study will include all clinically healthy patients with gingivitis and those with periodontitis (all stages and grades). Patients from diverse age groups will be analyzed to determine the prevalence of periodontitis in those below 25 years of age (early onset periodontitis) and to evaluate the variation in the genetic and microbial profile of such patients and those above 25 years.

Exclusion criteria

Exclusion criteria: All physically and mentally challenged individuals will be excluded. All participants with any systemic condition/ immunocompromising condition such as HIV, autoimmune diseases, or active infections such as tuberculosis, hepatitis, etc. will be excluded. Pregnant and lactating mothers will be excluded

Design outcomes

Primary

MeasureTime frame
1.Overall prevalence and changing trends of varying severity of periodontitis in the Udupi district according to the 2017 classification of PD from 2000-2024 2.Prevalence of the rapidly progressing form of periodontitis (PD) (Stage III/IV grade C) among individuals below 25 years of age. 3.Genetic variants/mutation in individuals with healthy and varying severity of PD (including Stage III/IV grade C).Timepoint: baseline—

Secondary

MeasureTime frame
1. Microbial profile of patients with gingival health, gingivitis, and PD/ perimplantitis (All stages and grades). 2. Levels of E. gingivalis in patients with gingival health, gingivitis, PD (All stages and grades), and those with periimplantitis. 3. Periodontal clinical parameters (presence or absence of interdental papillae; full-mouth bleeding on probing (presence or absence), full-mouth probing pocket depth (in mm) and clinical attachment loss (CAL); the presence of any teeth with mobility/ furcation/ recession; degree of alveolar bone loss on dental radiographs (in mm); DMFT, BMI, other demographic variables as described previouslyTimepoint: Baseline—

Countries

India

Contacts

Public ContactAditi Chopra

Manipal College of Dental Sciences, Manipal

draditichopra@gmail.com08292922173

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026