To study the effect of curcumin ( intervention) in 2 group of participants on healing and infection in operated cases of maxilla with obturator prosthesis treatment.

To study the effect of curcumin on inflammatory markers and microbial flora in hemimaxillectomy patients with obturator prosthesis: a randomised controlled study - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/069938

Enrollment

Registered

2024-07-04

Start date

Unknown

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C059- Malignant neoplasm of palate, unspecified

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adults who are capable of giving informed consent and willing to participate in the study. 2. Unilateral surgically operated hemimaxillectomy patients.

Exclusion criteria

Exclusion criteria: 1. People with debilitating diseases and other co-morbidities. 2. People under medication with immunosuppressant drugs. 3. People under anti inflammatory drugs for other chronic diseases like arthritis, osteoporosis etc. 4. People undergoing radiation.

Design outcomes

Primary

Measure	Time frame
To analyze and compare levels of IL 1Beta and TNF Alpha at different level with and without curcumin therapy in patients treated with obturator prosthesis.Timepoint: 0, 1, 2 and 4 weeks	—

Secondary

Measure	Time frame
To analyze and compare aerobic, anaerobic and fungal microbial flora at different time interval with and without curcumin therapy in patients treated with onturator prosthesis.Timepoint: 1 day 1 week 2 weeks 4 weeks;to assess Quality of Life (QOL) of patients at different time interval with and without curcumin therapy in patients treated with obturator prosthesisTimepoint: 1 day 1 week 2 weeks 4 weeks;To clinically assess and compare the healing at local site, subjectively and objectively in cases of hemimaxillectomy patients with curcumin therapy with obturator prosthesis at regular time interval.Timepoint: 1 day 1 week 2 weeks 4 weeks	—

Measure

Time frame

To analyze and compare aerobic, anaerobic and fungal microbial flora at different time interval with and without curcumin therapy in patients treated with onturator prosthesis.Timepoint: 1 day 1 week 2 weeks 4 weeks;to assess Quality of Life (QOL) of patients at different time interval with and without curcumin therapy in patients treated with obturator prosthesisTimepoint: 1 day 1 week 2 weeks 4 weeks;To clinically assess and compare the healing at local site, subjectively and objectively in cases of hemimaxillectomy patients with curcumin therapy with obturator prosthesis at regular time interval.Timepoint: 1 day 1 week 2 weeks 4 weeks

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Countries

India

Contacts

Public ContactYangchin Drema

King George’s Medical University, Lucknow

dr.pooran_chand@yahoo.com9415173419

Outcome results