Health Condition 1: O048- (Induced) termination of pregnancywith other and unspecified complications
Conditions
Interventions
Intervention1: Intra amniotic digoxin: Single dose of 1mg digoxin is injected intra-amniotically under ultrasound guidance to cause intra-uterine fetal demise followed by medical termination of pregna
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: Woman with singleton pregnancy, equal to or more than 20 weeks of gestation opting for termination of pregnancy Documented fetal cardiac activity
Exclusion criteria
Exclusion criteria: Chronic maternal illness (previous or active heart disease, chronic kidney or liver disease) Preterm premature rupture of membranes Abnormal serum potassium levels (below 3.5mmol/l or above 5.5 mmol/l) Abnormal ECG Known maternal digoxin hypersensitivity More than 24 weeks of gestation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effectiveness of digoxin in inducing fetal death as determined by absence of fetal heartbeat on ultrasound 24 hours after the procedure. Comparison of Induction-Abortion interval of mid-trimester abortions in women with or without intra-amniotic digoxin administration.Timepoint: 24 hours after administration of intra-amniotic digoxin | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of the following parameters in women undergoing mid-trimester MTP with or without intra-amniotic digoxin instillation Success rate of mid-trimester abortions is defined as complete expulsion of products of conception Number of doses of misoprostol required Maternal systemic side effects in both the groups Timepoint: Interval between first dose of misoprostol and last dose of misoprostol | — |
Countries
India
Contacts
Public ContactDr. Manisha
University College of Medical Sciences and Guru Teg Bahadur Hospital
Outcome results
None listed