Effect of application of Glutathione with Vitamin c gel and Glutathione Gel alone after Gingival depigmentation surgery

Comparative evaluation of the effectiveness of Glutathione with Vitamin-C gel and Glutathione gel on gingival pigmentation after gingival depigmentation surgery-A split mouth randomized case control trial. - NIL

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/069885

Enrollment

Registered

2024-07-04

Start date

Unknown

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K051- Chronic gingivitis

Interventions

Intervention1: Glutathione with Vitamin C gel: Glutathione with Vitamin C gel will be applied on 12 sites for 5 minutes after gingival depigmentation surgery Control Intervention1: Glutathione Gel: Gl

Eligibility

Inclusion criteria

Inclusion criteria: 1.Systemically healthy people with moderate to severe pigmentation based on Dummetts Index (1964). 2.Patients above 18 years of age.

Exclusion criteria

Exclusion criteria: 1.Pregnant and lactating mothers. 2.Family history of skin cancer. 3.Fully edentulous patients. 4.Smokers 5.Patients who are taking medications that influence gingival colour. 6.Patients with any systemic disease that may induce production of melanin. 7.Patients allergic to Glutathione or Vitamin C.

Design outcomes

Primary

Measure	Time frame
Dummett Oral Pigmentation Index 0 No clinical pigmentation 1 Mild clinical pigmentation 2 Moderate clinical pigmentation 3 Heavy clinical pigmentationTimepoint: 1month and 3months	—

Secondary

Measure	Time frame
Visual Analog scale (Steigmann, 1965)Timepoint: 7 days and one month	—

Countries

India

Contacts

Public ContactDrPrashanth Shetty

Yogita dental college and hospital

khushee12@gmail.com9833441360

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026