Comparison of continuous infusion of valproate vs midazolam in children aged 3months to 18 years of refractory seizures.

Comparison of the continuous intravenous infusion of sodium valproate vs midazolam on management of refractory status epilepticus in children admitted in Pediatric Intensive Care Unit - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/069881

Enrollment

Registered

2024-07-04

Start date

Unknown

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G042- Bacterial meningoencephalitis andmeningomyelitis, not elsewhere classified

Interventions

Intervention1: Sodium valproate: 10 mg/kg/day continuous infusion to 60mg/kg/day for 24 hrs and then tapering Control Intervention1: Iv midazolam: Starting from 8microgram/kg/ day infusion for 24 hour

Eligibility

Inclusion criteria

Inclusion criteria: Children admitted with refractory seizures ( no response even after 2 antiepileptics) in children aged 3 months to 18 years in PICU.

Exclusion criteria

Exclusion criteria: Child with metabolic disorders are not included in the study.

Design outcomes

Primary

Measure	Time frame
Decrease in seizure burden 2. Adequacy of seizure control 3. Rapidity of seizure control 4. Adverse effects Timepoint: 30 minutes	—

Secondary

Measure	Time frame
Adverse effects of drugsTimepoint: 1 week	—

Countries

India

Contacts

Public ContactMeera Mohan

Shyam Shah medical college Rewa

deepakdwi72@gmail.com7869918636

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026