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To see if local application of tranexamic acid reduces seroma formation in patients undergoing ventral hernia surgery

To compare the incidence of seroma formation with or without local application of tranexamic acid in ventral herioplasty -a randomized control trial - NIL

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/07/069878
Enrollment
98
Registered
2024-07-04
Start date
Unknown
Completion date
Unknown
Last updated
2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K439- Ventral hernia without obstructionor gangrene

Interventions

Intervention1: To reduce seroma formation in ventral hernioplasty using tranexamic acid: Tranexamic acid is applied under the skin flap and skin is closed, daily drain output is measured from day 1 to

Sponsors

Janani Devi Colon
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patient having ventral hernia aged between 18 years to 80 years are included in the study. Both male and female genders are included. Hernial Defect size more than 2cms. patient who are able to understand the merits and demerits.

Exclusion criteria

Exclusion criteria: Patient having ventral hernia aged less than 16 years and above 80 years are excluded from the study. Cirrhosis Uncontrolled Diabetes Mellitus, chronic kidney disease not willing to participate in the trial BMI more than 35 recurrence, Strangulated hernia, pregnancy patient with severe anaemia

Design outcomes

Primary

MeasureTime frame
Reduction in Seroma formation is measured in test group (using tranexamic acid) than the control group ( using normal saline)Timepoint: daily drain output till day 5 of postoperative period is estimated and compared with control group

Secondary

MeasureTime frame
reduction of seroma formation using application of tranexamic acid compared with normal salineTimepoint: first 5 days of post operative period

Countries

India

Contacts

Public ContactJanani Devi Colon

Sri manakula vinayagar medical college and hospital

gvmanoharan14@gmail.com9894585170

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026