Comparing lung related complications of Sugammadex and Neostigmine used for coming out of general anesthesia after oral and dental surgeries.

A Prospective comparative study of reversal of residual neuromuscular block with neostigmine versus sugammadex and post operative pulmonary complications in oral and orthodontic surgeries. - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/069800

Enrollment

172

Registered

2024-07-02

Start date

Unknown

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K137- Other and unspecified lesions of oral mucosa

Interventions

Intervention1: Reversal of residual neuromuscular blockade using conventional neostigmine with glycopyrrolate.: Patient undergoing general anaesthesia with rocuronium-based neuromuscular block will be

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients belonging to American Society Of Anesthesiologists Physical Status I and II. 2) Patients undergoing elective oral and orthodontic surgeries

Exclusion criteria

Exclusion criteria: 1) Patient refusal to give consent for the procedure. 2) Patients with preexisting respiratory disorders. 3) Patient with neuromuscular disorders.

Design outcomes

Primary

Measure	Time frame
Need for tracheal re-intubation identified by failure Of extubation criteria. Extubation criteria: A) Breathing spontaneously B) Following commands C) 5 seconds sustained head lift D) Airway clear of debris E) Adequate pain Control Timepoint: The above mentioned parameters will be assessed at 30th second,2 minutes,10 minutes and 30 minutes after tracheal extubation.	—

Secondary

Measure	Time frame
1) Desaturation of less than 95% 2) Bronchospasm: A) Prolonged expiration with wheeze, B) Reduced or Absent breathe sounds on auscultation. 3) Laryngospasm: A) Increased respiratory efforts, B) Paradoxical breathing, & C) Inspiratory stridor. 4) Tachycardia or Bradycardia after reversal for more or less than 20% of baseline respectively. 5) Post Operative Nausea & Vomiting. Timepoint: The above mentioned parameters will be assessed at 30th second, 2 minutes, 10 minutes & 30 minutes after tracheal extubation.	—

Measure

Time frame

1) Desaturation of less than 95% 2) Bronchospasm: A) Prolonged expiration with wheeze, B) Reduced or Absent breathe sounds on auscultation. 3) Laryngospasm: A) Increased respiratory efforts, B) Paradoxical breathing, & C) Inspiratory stridor. 4) Tachycardia or Bradycardia after reversal for more or less than 20% of baseline respectively. 5) Post Operative Nausea & Vomiting. Timepoint: The above mentioned parameters will be assessed at 30th second, 2 minutes, 10 minutes & 30 minutes after tracheal extubation.

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Countries

India

Contacts

Public ContactDr Ramesh Babu

Navodaya Medical College,Hospital and Research and Centre

rsjev6313@gmail.com9972612229

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026