A study to compare the routine clinical evaluation based versus nerve stimulating muscle response monitor guidance for evaluation of adequacy of muscle recovery before removal of tube from trachea and its impact on lung function after surgery in patients undergoing General anaesthesia.

Comparison of standard clinical assessment based decision with Quantitative Neuromsucular monitor guidance for evaluation of the adequacy of neuromuscular recovery before tracheal extubation and Its Impact on Postoperative spirometry in Patients Undergoing General anaesthesia. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/069781

Enrollment

Registered

2024-07-01

Start date

Unknown

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Acceleromyography group: Assessment of neuromuscular function recovery using quantitative neuromuscular monitoring (numerical TOF ratio) based extubation in patients undergoing general

Eligibility

Inclusion criteria

Inclusion criteria: American society of anaesthesiology (ASA) physical status I and II undergoing elective surgery under general anaesthesia

Exclusion criteria

Exclusion criteria: Patients with ASA status III and above,Pregnant women,Patients with history of neuromuscular diseases,on medications that interfere with neuromuscular junction function,renal, hepatic or respiratory disease,BMI greater than 35kg per m2,Pre operative hypothyroidism,undergoing brain or thoracic surgery

Design outcomes

Primary

Measure	Time frame
a) Compare postoperative Forced Vital Capacity (FVC) and Peak Expiratory Flow (PEF) reductions in the immediate first hour postoperative period in patients with RNMB following the reversal strategy either using TOF monitor versus standard conventional clinical judgment. b) Number of patients with residual NMB in both the groups and time to achieve TOF of 1.0 post extubation in PACU Timepoint: a) PFT - Preoperatively baseline and 30 mins,1hr,1hr 30 mins, 2hrs postoperatively b) TOF ratio - every 5 mins upto 1 hr	—

Measure

Time frame

a) Compare postoperative Forced Vital Capacity (FVC) and Peak Expiratory Flow (PEF) reductions in the immediate first hour postoperative period in patients with RNMB following the reversal strategy either using TOF monitor versus standard conventional clinical judgment. b) Number of patients with residual NMB in both the groups and time to achieve TOF of 1.0 post extubation in PACU Timepoint: a) PFT - Preoperatively baseline and 30 mins,1hr,1hr 30 mins, 2hrs postoperatively b) TOF ratio - every 5 mins upto 1 hr

—

Secondary

Measure	Time frame
To compare the following parameters between the 2 groups adverse respiratory events 1) Hypoxia (SpO2 less than 90%) 2) Respiratory distress RR greater than 30 3) upper airway obstructionTimepoint: 2 hr	—

Countries

India

Contacts

Public ContactDr MV Vidya

Pondicherry Institute of Medical Sciences

siva85dr@gmail.com9944060676

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026