Haemodynamic effects of carbetocin versus oxytocin for bleeding control in caesarean section patients

Comparison of Haemodynamic effects of intravenous carbetocin versus oxytocin for the prevention of postpartum haemorrhage in patients undergoing Caesarean section under subarachnoid block- A double blind randomized controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/069773

Enrollment

Registered

2024-07-01

Start date

Unknown

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O721- Other immediate postpartum hemorrhage Health Condition 2: O00-O9A- Pregnancy, childbirth and the puerperium

Interventions

Intervention1: Carbetocin: intravenous carbetocin 100 micrograms bolus over 1 minute Control Intervention1: Oxytocin: intravenous oxytocin 5 IU bolus over 1 minute followed by 10 IU/h for 4 hours.

Eligibility

Inclusion criteria

Inclusion criteria: All pregnant patients aged 18 years and above belonging to american society of anaesthesiologists physical status I/II

Exclusion criteria

Exclusion criteria: Patients with 1. Antepartum haemorrhage 2. Severe preeclampsia 3. Uterine rupture 4. Severe Cardiac,Hepatic and Renal disorders 5. Bleeding /coagulation disorders 6. Hypersensitivity to the study medication

Design outcomes

Primary

Measure	Time frame
To compare the haemodynamic effects (Heart rate, Systolic, diastolic and Mean arterial Pressures) of carbetocin versus oxytocin for the prevention of postpartum haemorrrhage in parturients undergoing caeserean sectionTimepoint: at 0,1,3,5,10,15,20,25,30 minutes.Every 15 minutes for 1 hour and every half an hour for 4 hours thereafter	—

Secondary

Measure	Time frame
To compare 1. The uterine tone betweem the two groups 2. The requirement of additional uterotonic drugs between two groups 3. Haemoglobin/Haematocrit before and 24 hours after the surgical procedure Timepoint: 1. at 0,1,3,5,10,15,20,25,30 minutes.Every 15 minutes for 1 hour and every half an hour for 4 hours thereafter 2.at 0,1,3,5,10,15,20,25,30 minutes.Every 15 minutes for 1 hour and every half an hour for 4 hours thereafter 3. before surgery and 24 hours after surgery	—

Measure

Time frame

To compare 1. The uterine tone betweem the two groups 2. The requirement of additional uterotonic drugs between two groups 3. Haemoglobin/Haematocrit before and 24 hours after the surgical procedure Timepoint: 1. at 0,1,3,5,10,15,20,25,30 minutes.Every 15 minutes for 1 hour and every half an hour for 4 hours thereafter 2.at 0,1,3,5,10,15,20,25,30 minutes.Every 15 minutes for 1 hour and every half an hour for 4 hours thereafter 3. before surgery and 24 hours after surgery

—

Countries

India

Contacts

Public ContactDr Abinaya R

Pondicherry Institute of Medical Sciences

abinayaramachandran.91@gmail.com04132651127

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026