Comparative evaluation of intraoperative use of two intravenous fluids(Normal Saline alone versus Normal Saline and Ringers Lactate administered alternatively as maintenance IV fluid in patients undergoing elective neurosurgery

Comparative Evaluation of intra operative use of Normal Saline Versus Normal Saline and Ringers Lactate administered alternatively as maintenance IV fluid in patients undergoing elective neurosurgery :A Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/069745

Enrollment

Registered

2024-07-01

Start date

Unknown

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: Group normal saline and ringers lactate.: Intraoperatively for whole duration of surgery alternate normal saline and ringers lactate will be given. Duration-from starting of surgery to

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients undergoing elective brain surgeries 2.ASA physical status grade 1 and 2 3 patients age group between 18 -60 4.Patients with preoperative GCS morethan or equal to 13 5.BMI less than or equal to 30

Exclusion criteria

Exclusion criteria: 1.Patients with pre exixting renal failure (Defined ASD serum creatinine more than 2) 2.Patients with electrolyte imbalance 3.Patients who are already receiving mannitol 4.Patients having Diabetes Mellitus 5.Patients with harmone secreting tumors 6.Patients on steroids for longer durations 7.Intraoperative blood loss more than 1000ml 8.Prolonged surgeries(duration exceeding 6 hrs)

Design outcomes

Primary

Measure	Time frame
Preoperative and postoperative calculated serum osmolarity at defined intervalsTimepoint: 1.On morning of surgery 2.6 hours after surgery 3.On first post operative day at 9 AM	—

Secondary

Measure	Time frame
1.Preoperative & post operative serum electrolytes at defined intervals 2.Preoperative & postoperative blood sugars at defined intervals 3.Preoperative & post operative glasgow coma scale 4.Brain relaxation score as assessed by neurosurgeons 5.Total volume of IV fluids administered in 1st six hours of surgery 6. Intraoperative blood loss 7.Duration of surgeryTimepoint: 1.On morning of surgery 2.6 hours after initiation of surgery 3.On first post operative day at 9AM	—

Measure

Time frame

1.Preoperative & post operative serum electrolytes at defined intervals 2.Preoperative & postoperative blood sugars at defined intervals 3.Preoperative & post operative glasgow coma scale 4.Brain relaxation score as assessed by neurosurgeons 5.Total volume of IV fluids administered in 1st six hours of surgery 6. Intraoperative blood loss 7.Duration of surgeryTimepoint: 1.On morning of surgery 2.6 hours after initiation of surgery 3.On first post operative day at 9AM

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Countries

India

Contacts

Public ContactDR BALA SUBRAMANYA H

Department Of Anaesthesiology And Critical Care, VIMS, Ballari.

srinijasri0308@gmail.com7013918705

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026