Health Condition 1: M458- Ankylosing spondylitis sacral andsacrococcygeal region Health Condition 2: M458- Ankylosing spondylitis sacral andsacrococcygeal region
Conditions
Interventions
Intervention1: Ultrasound guided administration of injection Triancelonose (40mg) in each sacro-iliac (S.I.) joint - single intervention: Patients with Active axial spondyloarthritis, defined by Bath
Sponsors
INSTITUTE OF NEUROSCIENCES KOLKATA
Eligibility
Inclusion criteria
Inclusion criteria: i. Patients = 18 years of age ii. Fulfilling the ASAS classification criteria of Axial Spondyloarthritis 2011. iii. Active disease defined by Bath ankylosing spondylitis disease activity index (BASDAI) score = 4, or ASDAS = 2.1.
Exclusion criteria
Exclusion criteria: 1. Bony ankylosis of sacroiliac joint - Grade 4 sacroilitis according to the modified New York criteria 2. Patients with only peripheral spondyloarthropathy 3. Predominantly Psoriatic arthritis 4. Predominantly Enteropathic arthritis 5. Patients on biologics and JAK inhibitors 6. Allergy to etoricoxib 7. Contraindication to NSAIDs 8. Pregnancy or lactation at the time of study entry 8. Infective sacroiliitis 10. History of corticosteroid injection in the sacroiliac joint within six months before study entry 11. Malignancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decrease of spinal pain score (VAS 0-10 scale) at 12 weeksTimepoint: 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Any adverse effect in both the armsTimepoint: 12 weeks;ASDAS (Ankylosing Spondylitis Disease Activity Score) improvementTimepoint: 12 weeks;Bath ankylosing spondylitis disease activity index (BASDAI) 50 responseTimepoint: 12 weeks;NSAID index at 12 weeksTimepoint: 12 weeks;Reduction in CRP levels in blood at 12 weeksTimepoint: 12 weeks | — |
Countries
India
Contacts
Public ContactDr. Shyamashis Das
Institute of Neurosciences Kolkata
Outcome results
None listed