Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: intravenous dexmedetomidine: injection Dexmedetomidine is given at a dose of 1 µg/kg in 10ml normal saline intravenously over 10 minutes
Control Intervention1: intravenous labetalol: in
Sponsors
Rajendra Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: ASA Grade I & II ,Elective surgery requiring general anesthesia with endotracheal intubation
Exclusion criteria
Exclusion criteria: Patient contraindicated to beta blockers,Hypertensive patients,patients on anti hypertensives,Systolic BP less than 120 mm of hg , HR less than 60/min,Evidence of anticipated difficult airway,Drug allergy to dexmedetomidine and labetalol,Pregnant patients,Ischemic heart disease,Cerebrovascular accidents,patient refusal,intubation attempts more than 2 times
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the efficacy of dexmedetomidine 1 µg/kg and labetalol 0.3 mg/kg in blunting the hemodynamic stress response to laryngoscopy and intubationTimepoint: 1)after drug administration 2)after induction 3)1 minute after induction 4)2 minute after induction 5)3 minute after induction 6)5 minute after induction 7)10 minute after induction 8)15 minute after induction | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)To observe for any adverse effect related to dexmedetomidine and labetalol 2)To determine and compare the level of sedation achieved before intubation after administration of dexmedetomidine and labetalolTimepoint: 1)after drug administration 2)after induction 3)1 minute after induction 4)2 minute after induction 5)3 minute after induction 6)5 minute after induction 7)10 minute after induction 8)15 minute after induction | — |
Countries
India
Contacts
Public ContactDr Ramesh Kumar Kharwar
Rajendra Institute of Medical Sciences
Outcome results
None listed