Comparison of Neostigmine and Sugammadex as muscle paralysis reversal agents by assessing respiratory muscle strength and lower lung collapse after operation with the help of Diaphragm, Lung, and respiratory muscle ultrasonography

Comparison of Neostigmine and Sugammadex reversal of neuromuscular blockade on postoperative muscle strength and postoperative lung atelectasis by respiratory muscle, diaphragm and lung ultrasonography: a double-blind randomized controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/07/069731

Enrollment

192

Registered

2024-07-01

Start date

Unknown

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: sugammadex as reversal agent: Sonographic assessments : Lung, Diaphragm and respiratory muscle thickness ultrasonography will be performed by using 2-5 MHZ transducers. Images will be

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anaesthesiologists physical status 1-2 Able to give Informed consent.

Exclusion criteria

Exclusion criteria: significant liver and kidney disease. Allergic to neostigmine or sugammadex. Any history of neuromuscular disorder. History of Chronic Obstructive Pulmonary Disease. Pregnancy or nursing women Open Abdominal surgeries with subcostal incisions. Patients with arrhythmias or taking anti-arrhythmic drugs. surgeries anticipated to last more than 3 hours.

Design outcomes

Primary

Measure	Time frame
To assess the recovery of respiratory muscle strength by assessing the thickening fraction of internal oblique muscleTimepoint: calculated at 30 minutes and 120 minutes after giving reversal agent and compare with baseline values	—

Secondary

Measure	Time frame
To assess the post operative atelectasis by the modified LUS score based on lung ultrasound. To assess the recovery of diaphragm, by assessing diaphragm excursion. To assess the displacement of hyoid bone by initially assessing the length of the geniohyoid muscle in the mid-sagittal plane between hyoid bone and mandibleTimepoint: calculated at 30 minutes and 120 minutes after giving reversal agent and compare with baseline values	—

Measure

Time frame

To assess the post operative atelectasis by the modified LUS score based on lung ultrasound. To assess the recovery of diaphragm, by assessing diaphragm excursion. To assess the displacement of hyoid bone by initially assessing the length of the geniohyoid muscle in the mid-sagittal plane between hyoid bone and mandibleTimepoint: calculated at 30 minutes and 120 minutes after giving reversal agent and compare with baseline values

—

Countries

India

Contacts

Public ContactDr.Nishant Sahay

AIIMS PATNA

nishantsahay@gmail.com9431184516

Outcome results