Health Condition 1: N200- Calculus of kidney
Conditions
Interventions
Intervention1: Multi-strain probiotic along with dietary counselling: Multi-strain probiotic capsule - Live freeze dried lactic acid bacteria and bifidobacteria in a concentration of112.5 Billion CFU,
Sponsors
Indian Council of Medical Research
Eligibility
Inclusion criteria
Inclusion criteria: 1)Newly diagnosed or recurrent kidney stone disease (KSD) patients diagnosed using ultrasonography (USG) abdomen of age 18 years or more at first presentation to our institute 2)Both symptomatic as well as asymptomatic cases will be included
Exclusion criteria
Exclusion criteria: 1)Any antibiotic usage in the prior 3 months 2)Any history of diarrhoea one month prior to randomization 3)Chronic diarrhoea, malabsorption or history of any bowel resection 4)Any laxative or probiotic usage in prior 1 month 5)Patients with known risk factors for KSD such as primary hyperparathyroidism, distal RTA, gouty arthritis, polycystic kidney disease etc. 6)Cases of acute or chronic infections, malignancies, immunosuppression 7)Chronic kidney disease (CKD) with eGFR less than 30ml/min/1.72m2 (CKD-EPI formula) 8)Symptomatic stones requiring Urological intervention 9)Not consenting for the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1)Difference in 24 hour urinary parameters between the two arms and between baseline and at the end of 12 weeks post randomization. 2)Difference in the gut microbiota profile between the two arms and between baseline and end of 12 weeks.Timepoint: 12 weeks after randomization | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)Difference in USG profile between the two arms and between baseline and at the end of 12 weeks post randomization.Timepoint: 12 weeks after randomization | — |
Countries
India
Contacts
Public ContactDr Anitha Swamy
All India Institute of Medical Sciences, Bibinagar, HMR
Outcome results
None listed