Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Sterofundin: Balanced salt solution with relatively high chloride concentration and low Strong ion difference
Control Intervention1: Plasmalyte: Balanced salt solution with relatively l
Sponsors
Postgraduate Institute of Medical Education and Research Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: Patients between age 18 to 70 years undergoing elective major abdominal surgery (more than 2 hours of projected operating time) ASA-PS class 1, 2 and 3
Exclusion criteria
Exclusion criteria: Patients who are hemodynamically unstable preoperatively Presence of preoperative metabolic acidosis (arterial pH lower than 7.2, lactate over 2 mmol per L, bicarbonate less than 16 mEq/L) Acute and, or chronic kidney disease Presence of preoperative fluid overload (pleural, pericardial effusion, ascites)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To estimate the difference in serum chloride and pH at the end of major abdominal surgery between the sterofundin and plasmalyte groupTimepoint: At the time of skin closure and before extubation | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare blood gas parameters (HCO3-, BE, pCO2, pO2), electrolytes (Na+, K+, Ca++, Mg++) and lactate at the end of surgery.Timepoint: At the end of surgery;To compare the difference in strong ion difference using stewarts approachTimepoint: At the time of skin closure and before extubation;To compare the prevalence of postoperative AKI as per KDIGO criteriaTimepoint: At the end of postoperative day 7;To compare the total volume of intraoperative crystalloids, colloids and blood products used.Timepoint: Intra operative period;To compare the Vasoactive Inotrope scores between the groupsTimepoint: At the end of surgery | — |
Countries
India
Contacts
Public ContactVenkata Ganesh
Post Graduate Institute of Medical Research
Outcome results
None listed