Mouthwash and resistance to antibiotics

Impact of chlorhexidine compared to a herbal mouthwash on antimicrobial resistance genes. A randomized control trial in patients with generalized gingivitis - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/069645

Enrollment

Registered

2024-06-27

Start date

Unknown

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K051- Chronic gingivitis Health Condition 2: K051- Chronic gingivitis

Interventions

Intervention1: 0.12% chlorhexidine mouthwash: One group of patients will be given 0.12% chlorhexidine mouthwash and they will be instructed to use 15ml of mouthwash twice daily for 2 weeks. Control In

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy patients with generalized gingivitis belonging to both sexes aged between 20- 30 years will be selected from the outpatient clinic of the Department of Periodontics

Exclusion criteria

Exclusion criteria: Pregnant and lactating females Immunocompromised patient Periodontal or orthodontic treatment at least 6 months before the start of the study Use of antibiotics, corticosteroids, and anti ?inflammatory drugs within 6 months before sampling. Patients who are regularly using chlorhexidine or similar mouthwashes.

Design outcomes

Primary

Measure	Time frame
Expression of TetM and Mef1 genes Timepoint: 2 weeks	—

Secondary

Measure	Time frame
Full mouth Bleeding Score Full mouth plaque score Probing pocket depthTimepoint: 2 weeks	—

Countries

India

Contacts

Public ContactAnnie Liz Manuel

PMS College of Dental Science and Research

ambilirenjith2020@gmail.com9447463676

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026