Health Condition 1: 4- Measurement and Monitoring
Conditions
Interventions
Control Intervention1: nil: nil
Sponsors
AIIMS, New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: . All patients age 18 years and above with the confirmed diagnosis of locally advanced non metastatic carcinoma- buccal mucosa who were deemed as borderline resectable on multi-disciplinary team discussion and received neo-adjuvant chemotherapy before definitive surgery from January 1 , 2019 to Feb 2023 at both the centres( retrospective study) . 2. For prospective part of study, all newly diagnosed locally advanced- non metastatic carcinoma buccal mucosa patients who will be fulfilling below mentioned criteria for borderline resectability will be included. a. Gingivo- buccal complex cancers with extensive skin involvement. b. Skin edema reaching upto the level of zygoma. c. Lateral pterygoid muscle, temporalis insertion or retroantral fat involvement. 3. Performance status: 0-1 4. Medically fit for definitive surgery
Exclusion criteria
Exclusion criteria: All patients with disease extension to infra-notch area and pterygo-maxillary fissure involvement will not be included in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Surgical conversion Rate 3.Clinical and radiological factors associated with operability and chemotherapy effectiveness: 4.To evaluate surgical margins in patients who received neo-adjuvant chemotherapy before surgery: 5.Surgical outcomesTimepoint: 3 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Total Duration of hospital stay after surgery: a. For calculation of number of days, day will be calculated from date of surgery to day of discharge. 2. Radiological assessment of tumor response post neo-adjuvant chemotherapy in prospectively involved patients: a. Response will be assessed as per RECIST guidelines Timepoint: 3 weeks | — |
Countries
India
Contacts
Public ContactDr Akash Mishra
All India Institute of Medical Sciences
Outcome results
None listed