Health Condition 1: Q612- Polycystic kidney, adult type
Conditions
Interventions
Intervention1: Metformin
: tablet Metformin at 1gm twice a day par orally for 12 months
Control Intervention1: Placebo: Similar looking Vitamin B tablets with Vitamin B12 750 microgram twice a day pa
Sponsors
IPGMER and SSKM hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients with ADPKD defined as per case definition between 18-65 years 2. eGFR > 45 ml/min/1.73 m2 as per CKD EPI 2021 equation. 3. Typical or Class 1 ADPKD on MRI.
Exclusion criteria
Exclusion criteria: 1. Patients with Diabetes mellitus. 2. Patients with liver disease (elevation of liver enzymes >2 times the baseline). 3. Females who were pregnant or breast feeding or unwilling to use contraception. 4. Congestive heart failure, 5. Unable to undergo MR imaging. 6. Subjects those were taking medications that interact with metformin like digoxin, quinidine, cimetidine. 7. Known hypersensitivity to metformin and its derivatives. 8. Psychiatric disorders and any condition that might prevent full comprehension of the purposes and risks of the study. 9. HIV, HBV, HCV infection. 10. Urinary tract obstruction. 11. Atypical Type 2 ADPKD on MRI
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| percentage change in Height adjusted total kidney volume by MRITimepoint: 1 year | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage change in estimated Glomerular Filtration rateTimepoint: 12 months | — |
Countries
India
Contacts
Public ContactAniruddha Datta
Department of Nephrology, Institute of Post Graduate Medical Education & Research
Outcome results
None listed