To study effectiveness of treatment with colistin based triple antimicrobial combination therapy versus minocycline based triple antimicrobial combination therapy in critically ill patients infected with carbapenem resistant Acinetobacter baumanni

Comparison of treatment failure with Minocycline versus Colistin Based Triple Antimicrobial Therapy for Carbapenem Resistant Acinetobacter Baumannii Infection in Critical Care Unit A Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/069529

Enrollment

100

Registered

2024-06-26

Start date

Unknown

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B968- Other specified bacterial agents as the cause of diseases classified elsewhere

Interventions

Intervention1: Minocycline based triple antimicrobial combination therapy: patients having blood cultures or respiratory tract specimen cultures (including semi-quantitative and/or quantitative cultur

Eligibility

Inclusion criteria

Inclusion criteria: Patients admitted in critical care unit of our hospital having either a bloodstream infection (BSI) and/or pneumonia due to MDR carbapenem resistant Acinetobacter Baumanni

Exclusion criteria

Exclusion criteria: Pregnant Patients,The presence of any of the following known clinical syndromes involving CRAB as a study pathogen which necessitate durations of antimicrobial therapies greater than 14 days: endocarditis, osteomyelitis, prosthetic joint infections, meningitis and/or other central nervous system infections. Patients with known severe drug allergy to either of the study drugs or to ß-lactams. Patients with polymicrobial infections. Refusal to participate in study.

Design outcomes

Primary

Measure	Time frame
Comparison of treatment failure after anti-CRAB treatment between minocycline versus colistin based triple antimicrobial therapy for carbapenem resistant Acinetobacter Baumannii Infection in critical care unit for a duration specified by protocolTimepoint: 3,5,7,10,12th day or within 24 hours after the end of study therapy	—

Secondary

Measure	Time frame
Comparison of microbiological response, all-cause mortality after 28 days, change in SOFA score from baseline, duration of mechanical ventilation, duration of ICU stay, incidence of toxicities related to treatment medications between minocycline versus colistin based triple antimicrobial therapy for carbapenem resistant Acinetobacter Baumanni Infection in critical care unitTimepoint: 3,5,7,10,12th day or within 24 hours after the end of study therapy	—

Measure

Time frame

Comparison of microbiological response, all-cause mortality after 28 days, change in SOFA score from baseline, duration of mechanical ventilation, duration of ICU stay, incidence of toxicities related to treatment medications between minocycline versus colistin based triple antimicrobial therapy for carbapenem resistant Acinetobacter Baumanni Infection in critical care unitTimepoint: 3,5,7,10,12th day or within 24 hours after the end of study therapy

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Countries

India

Contacts

Public ContactPooja Bhardwaj

AIIMS Rishikesh

bhardwajjpooja08@yahoo.com8270278628

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026