Health Condition 1: K740- Hepatic fibrosis
Conditions
Interventions
Intervention1: Endoscopic Variceal Ligation and Partial Splenic Embolization arm: Cirrhosis patients with hypersplenism having a platelet count of less than 100,000/ µLundergoing partial splenic embo
Sponsors
Jawaharlal Institute of Postgraduate Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: Cirrhotic patients having variceal bleed and portal hypertension with hypersplenism and thrombocytopenia in Group-1 Cirrhotic patients having variceal bleed and portal hypertension without hypersplenism and thrombocytopenia in Group-2
Exclusion criteria
Exclusion criteria: Patients less than 18 years of age and more than 75 years of age Previous therapy (splenectomy, PSE, tissue adhesive injection) to prevent rebleeding Bleeding from isolated gastric or ectopic varices Hepatocellular carcinoma or other malignant tumours Hepatic failure, and Child–Pugh class C with large amount ascites, or grade 3–5 hepatic encephalopathy, or severe coagulopathy Contraindications for PSE Pregnancy and lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1)To study the recurrence and variceal rebleeding rate in cirrhotic patients with hypersplenism undergoing Partial splenic embolization combined with endoscopic therapies 2)To study the recurrence and variceal rebleeding rate in cirrhotic patients undergoing endoscopic management alone. Timepoint: 2 years | — |
Secondary
| Measure | Time frame |
|---|---|
| To study the incidence of complications in cirrhosis patients with hypersplenism undergoing Partial splenic embolization combined with endoscopic variceal ligation.Timepoint: 2 years | — |
Countries
India
Contacts
Public ContactDhira Shobith Munipati
Jawaharlal Institute of Postgraduate Medical Education and Research
Outcome results
None listed