Effect of a local anaesthetic medication (lignocaine) in dose reduction of an intravenous anaesthetic agent used in obstructive sleep apnea patients undergoing sleep endoscopy procedure

Effect of lignocaine on dose reduction of propofol in propofol-dexmedetomidine based sedation for drug induced sleep endoscopy - a randomised double-blind controlled trial - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/069478

Enrollment

Registered

2024-06-26

Start date

Unknown

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: J398- Other specified diseases of upperrespiratory tract

Interventions

Intervention1: Drug administration: We give 1.5mg/kg dose of lignocaine infusion in 10ml syringe along with Dexmed, followed by maintenance of BIS and MOAA score with propofol boluses, mam We should n

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing DISE procedure for mild, moderate or severe obstructive sleep apnea

Exclusion criteria

Exclusion criteria: Known or suspected allergy to studied drugs Known or suspected allergy to studied drugs Patients with gross mandibular or maxillary deformity

Design outcomes

Primary

Measure	Time frame
Requirement of propofol with addition of lignocaineTimepoint: 5, 10, 15, 20, 25, 30, 40, 50 and 60 minutes	—

Secondary

Measure	Time frame
Any decline of blood pressure and heart rate to 20% from baselineTimepoint: 5, 10, 15, 20, 25, 30, 40, 50 and 60 minutes ;Number of Episodes of Oxygen desaturation (whenever SpO2 decreases to less than 90% and less than 80% noted separately)Timepoint: 5, 10, 15, 20, 25, 30, 40, 50 and 60 minutes;Surgeon and patient satisfaction evaluated by likert scaleTimepoint: at end of procedure;Time to attain MOAA/S(Modified Observer’s Assessment for Alertness/ Sedation) score=1 / BIS 60-70)/ snoringTimepoint: 5, 10, 15, 20, 25, 30, 40, 50 and 60 minutes;total duration of endoscopyTimepoint: 5, 10, 15, 20, 25, 30, 40, 50 and 60 minutes	—

Measure

Time frame

Any decline of blood pressure and heart rate to 20% from baselineTimepoint: 5, 10, 15, 20, 25, 30, 40, 50 and 60 minutes ;Number of Episodes of Oxygen desaturation (whenever SpO2 decreases to less than 90% and less than 80% noted separately)Timepoint: 5, 10, 15, 20, 25, 30, 40, 50 and 60 minutes;Surgeon and patient satisfaction evaluated by likert scaleTimepoint: at end of procedure;Time to attain MOAA/S(Modified Observer’s Assessment for Alertness/ Sedation) score=1 / BIS 60-70)/ snoringTimepoint: 5, 10, 15, 20, 25, 30, 40, 50 and 60 minutes;total duration of endoscopyTimepoint: 5, 10, 15, 20, 25, 30, 40, 50 and 60 minutes

—

Countries

India

Contacts

Public ContactSuman arora

PGIMPost-graduate Institute of medical science and ResearchER, Chandigarh

drsumanarora@hotmail.com9316025807

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026