Health Condition 1: C569- Malignant neoplasm of unspecifiedovary
Conditions
Interventions
Intervention1: Bupivacaine,Morphine: Epidural Bupivacaine infusion 0.1% at 4ml/hour plus single epidural morphine bolus 50mcg/kg ideal body weight from laparotomy incision till end of surgery
Control
Sponsors
Dr Nairita Das
Eligibility
Inclusion criteria
Inclusion criteria: 1)Age greater than 18 years 2)Carcinoma Ovary patients posted for elective open staging laparotomy 3)ASA (American Society of Anaesthesiologists) physical status 1,2 and 3 patients.
Exclusion criteria
Exclusion criteria: 1.Patients not consenting/contraindication to epidural. 2.ASA4 and above patients. 3.Low preoperative BP (systolic BP less than 100mmHg) either during pre-medication visit or the baseline vitals on shifting to operating theatre. 4.Patients with low ejection fraction (less than 50%) and/or regional wall motion abnormalities. 5.Patients declared inoperable after diagnostic laparoscopy. 6.Patients with allergy to any of the study drugs 7.Patients with severe or massive ascitis or in obstruction. 8.Patients with a low preoperative BMI less than 18.5 kg/m2. 9.Patients with marked hypoalbuminemia (Serum albumin less than 2.5 g/dL) 10. Any emergency surgeries.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Number of episodes of intraoperative hypotension (defined as mean arterial blood pressure less than 70 mmHg) from the time of laparotomy incision to two hours from laparotomy incision. 2. Mean of the mean arterial blood pressure (in mmHg) during these intra-operative hypotension episodes from laparotomy incision to two hours from laparotomy incision. Timepoint: Starting point of measurement: Time of laparotomy incision End point of measurement: two hours from the point of laparotomy incision | — |
Secondary
| Measure | Time frame |
|---|---|
| Maximum dose of noradrenaline requirement in mcg/kg/min to treat Intraoperative hypotension and duration of Noradrenaline requirement.Timepoint: From laparotomy incision to two hours from laparotomy incision. ;Total dose of ephedrine in milligrams and/or phenylephrine in micrograms to treat this Intraoperative hypotensionTimepoint: From laparotomy incision to two hours from laparotomy incision. | — |
Countries
India
Contacts
Public ContactDr Aravind Narayanan
Cancer Institute (WIA) Adyar, Chennai
Outcome results
None listed