Comparison study of Intravenous Dexmedetomidine and Intravenous Esmolol to diminished the Cardiovascular responses to laryngoscopy and endotracheal intubation in adult patients.

A Randomized Study of Comparison of I/V Dexmedetomidine and I/V Esmolol to Attenuate The Cardiovascular Responses to Laryngoscopy and Endotracheal Intubation in Adult Patient. - NILL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/069339

Enrollment

Registered

2024-06-20

Start date

Unknown

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: I/V DEXMEDETOMIDINE: Comparison Of Intravenous Dexmedetomidine to Attenuate The Cardiovascular Responses to Laryngoscopy and Endotracheal Intubation in Adult Patient,Dose-1mcg/kg,IV,Ov

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade 1 and 2, Mallampatti grade 1 and 2, Systolic blood pressure less than 140 mmHg, Diastolic blood pressure less than 90 mmHg, Heart rate 60-100 bpm, BMI 18.5 - 24.9 kgpm2

Exclusion criteria

Exclusion criteria: History of IHD, Heart disease, renal disease, pulmonary disease, liver disease. History of hypertension, History of dyspnea on exertion of grade 3 or more as per NYHA guidelines ASA grade 3 and 4 Mallampatti grade 3 and 4 Any contraindication of Dexmedetomidine and Esmolol

Design outcomes

Primary

Measure	Time frame
Attenuating the cardiovascular stress responses(Heart Rate,SBP,DBP,MAP,SPO2) accompanying laryngoscopy and endotracheal intubation.Timepoint: Attenuating the cardiovascular stress responses(SBP,DBP,MAP,SPO2) At Baseline(30 min prior to anaesthesia),Just after infusion of study drug, Before induction, After induction(just before intubation),Immediately after intubation, 1 min, 2min, 3min,4min,5min,10min after intubation accompanying laryngoscopy and endotracheal intubation.	—

Measure

Time frame

Attenuating the cardiovascular stress responses(Heart Rate,SBP,DBP,MAP,SPO2) accompanying laryngoscopy and endotracheal intubation.Timepoint: Attenuating the cardiovascular stress responses(SBP,DBP,MAP,SPO2) At Baseline(30 min prior to anaesthesia),Just after infusion of study drug, Before induction, After induction(just before intubation),Immediately after intubation, 1 min, 2min, 3min,4min,5min,10min after intubation accompanying laryngoscopy and endotracheal intubation.

—

Secondary

Measure	Time frame
Any adverse effect of drugs on Heart Rate(beats/min)SBP(mm of Hg),DBP(mm of Hg),MAP(mm of Hg),SPO2(%)Timepoint: At baseline,just after infusion of study drugs,before induction,after induction just before intubation,immediately after intubation,1min after intubation,2 min after intubation,3 min after intubation,4min after intubation,5min after intubation,10 min after intubation.	—

Countries

India

Contacts

Public ContactDR SUBHASH DAHIYA

Lala Lajpat Rai Memorial Medical College Meerut ,Uttar Pradesh

drsubhashllrm@gmail.com9837056949

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026