Comparing Two Methods of Corneal Treatment in Patients Aged 6-35 with Keratoconus

Comparison of efficacy between accelerated epithelium-off and accelerated epithelium-on corneal collagen crosslinking in patients with keratoconus - NIL

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/069279

Enrollment

Registered

2024-06-20

Start date

Unknown

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H186- Keratoconus Health Condition 2: H186- Keratoconus

Interventions

Intervention1: C3R using Ribofast dye: performing epi on C3R using ribofast dye. dye application 1 drop every minute for 30 minutes followed UV irradiation for 10 minutes with ribofast dye 1 drop per

Eligibility

Inclusion criteria

Inclusion criteria: 1)Central corneal thickness more than 400 microns at the thinnest point

Exclusion criteria

Exclusion criteria: a)Patients with history of trauma and prior ocular surgery b)Corneal scar or history of herpetic keratitis c)Active vernal keratoconjunctivitis

Design outcomes

Primary

Measure	Time frame
1)Change in maximum keratometry (Kmax) at 6 monthsTimepoint: 6 months	—

Secondary

Measure	Time frame
1)Demarcation line on anterior segment OCT at 1 month 2)Change in best corrected visual acuity (BCVA) at 6months 3)Endothelial cell density at 6 months Timepoint: 1 month,6 months	—

Countries

India

Contacts

Public ContactDr Pushkar Rangari

Department of Ophthalmology Maulana Azad Medical College And associated G.N.E.C

pushkarrangari@gmail.com9820089224

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026