Effect of Homoeopathic treatment for manic patient

An open label Randomized placebo-controlled trial of Individualized Homoeopathic Medicine Versus Placebo as an Add-On to Standard Treatment in Manic Episode-A Pilot study. - Nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/069264

Enrollment

Registered

2024-06-20

Start date

Unknown

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F303- Manic episode in partial remission Health Condition 2: F301- Manic episode without psychotic symptoms Health Condition 3: F302- Manic episode, severe with psychotic symptoms Health Condition 4: F309- Manic episode, unspecified

Interventions

Intervention1: Individualised Homoeopathic Medicine: This group will be treated with individualised Homoeopathic Medicine along with standard treatment . route of administration-oral. Duration-2years

Eligibility

Inclusion criteria

Inclusion criteria: Patients of both genders between 20-60 years of age diagnosed with mania or manic episodes of Bipolar Affective Disorders with or without psychotic symptoms.

Exclusion criteria

Exclusion criteria: 1. Patients diagnosed with Bipolar II disorder. 2. Patients with anti-social personality disorder. 3. Mental and behavioural disorders due to psychoactive Substance abuse. 4. Organic mental disorders such dementia, delirium. 5. The patients who are taking treatment for mania from any other system of medicines. 6. Patients who are having suicidal thoughts.

Design outcomes

Primary

Measure	Time frame
To compare the time span for bringing remission from baseline to end of manic symptoms as assessed by the YMRS.Timepoint: To compare the time span for bringing remission from baseline to end of manic symptoms as assessed by the YMRS. If the patients have very severe manic symptoms or tendency to make harm to him or others, he will be admitted in IPD and daily follow-ups will be taken. If symptoms severity or intensity is reduced, the patients will be advised to visit fortnightly for six months. Thereafter, monthly follow-ups will be taken for seventeen months.	—

Measure

Time frame

To compare the time span for bringing remission from baseline to end of manic symptoms as assessed by the YMRS.Timepoint: To compare the time span for bringing remission from baseline to end of manic symptoms as assessed by the YMRS. If the patients have very severe manic symptoms or tendency to make harm to him or others, he will be admitted in IPD and daily follow-ups will be taken. If symptoms severity or intensity is reduced, the patients will be advised to visit fortnightly for six months. Thereafter, monthly follow-ups will be taken for seventeen months.

—

Secondary

Measure	Time frame
i)To assess changes in YMRS BPRS. ii) To find out the improvement in functional impairments with FAST (Functional Assessment Short Test) between the groups. iii) Compare the relapse between the groups. iv) To evaluate reduction of medicine and dosage of Standard Treatment between the groups. Timepoint: 2years	—

Countries

India

Contacts

Public ContactDr S Karunakara Moorthi

National Homoeopathy Research Institute in Mental Health

dr.karunakaramoorthi@gmail.com08281502571

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026