Health Condition 1: F840- Autistic disorder
Conditions
Interventions
Intervention1: Propranolol: Beta adrenergic antagonist. It will be started at the dose of 1 mg per day and will be up titrated to a maximum dose of 1.5 mg per day, and it will be given for a period of
Sponsors
Government Medical College and Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diagnosis of autism spectrum disorder confirmed by DSM-5. 2. Age range should be 4-12 years 3. Any gender 4. Caregivers willing to give consent and children (> 7 years old) willing to give assent.
Exclusion criteria
Exclusion criteria: 1. Children with co-morbid psychiatric illness except attention deficit hyperactivity disorder (ADHD) 2. Children with Substance Use Disorders. 3. Children with evidence of organic brain syndrome or moderate to severe intellectual disability. 4. Children with any chronic medical conditions such as epilepsy, diabetes mellitus or on medications for the same. 5. Children with current reactive airway disease, untreated thyroid disease, bradycardia, hypotension, unexplained syncope, current major depression, taking medications that interact with propranolol (e.g., alpha-2 agonists). 6. Children on treatment with propranolol or risperidone in the past. 7. Children with family history of Asthma. 8. Children who are nonverbal from the start.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect of treatment on social communication and restricted/repetitive behaviors on children with Autism Spectrum DisorderTimepoint: 0,2,4,8,12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Effect of treatment on behavioral and anxiety symptoms of Autism Spectrum Disorder and compare side effect profile of both the drugsTimepoint: 0,2,4,8,12 weeks | — |
Countries
India
Contacts
Public ContactDr. Shivangi Mehta
Government Medical College and Hospital, Sector-32, Chandigarh
Outcome results
None listed