Comparison of efficacy between dwek that is removal of descemet layer of cornea and dwek with topical ripasudil in patients suffering from Fuchs endothelial corneal dystrophy .

Comparison of efficacy between descemetorhexis without endothelial keratoplasty (DWEK) with or without topical rho kinase inhibitor in Fuch’s endothelial corneal dystrophy (FECD). - NIL

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/069209

Enrollment

Registered

2024-06-19

Start date

Unknown

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H185- Hereditary corneal dystrophies

Interventions

Intervention1: DWEK (Descemetorhexis without endothelial keratoplasty ): Patients will undergo phacoemulsification followed by intraocular lens placement . The anterior chamber will be filled with vis

Eligibility

Inclusion criteria

Inclusion criteria: Adults with Fuchs dystrophy diagnosed clinically with cataract . Dense central guttae limited to central 5mm of cornea . Central stromal edema with visually significant complaints, morning blur . Clear peripheral cornea with an endothelial cell count of more than 1000 cells / mm square .

Exclusion criteria

Exclusion criteria: Advanced corneal edema defined as the presence of bullae or scarring . Presence of secondary corneal pathology such as infective or autoimmune keratitis . All patients with any retinal pathology ,advanced glaucoma corneal edema other than FECD. Patients on hormonal therapy /Oral contraceptive pills.

Design outcomes

Primary

Measure	Time frame
Change in central corneal thicknessTimepoint: Preop ,post op day 1 ,at 1 month ,then monthly till 6 months	—

Secondary

Measure	Time frame
Change in endothelial cell count in central and periphery .Timepoint: 6 months	—

Countries

India

Contacts

Public ContactDr Avinash Pradhan

Guru Nanak Eye Centre

hnapradhan18@gmail.com01123234622

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026