Health Condition 1: C00-C14- Malignant neoplasms of lip, oral cavity and pharynx
Conditions
Interventions
Intervention1: Concurrent chemotherapy: Concurrent chemotherapy in the form of cisplatin at 40mg/sq.m weekly to total of 6 cycles along with radiotherapy 60Gy in 30fractions for 6 weeks for postoperat
Sponsors
Department Of Radiotherapy and Radiation medicine
Eligibility
Inclusion criteria
Inclusion criteria: Histologically proven postoperative oral cavity carcinoma, squamous-cell carcinoma histology, three or more minor risk factors (include T4/T3 disease, multiple lymphnodes, a surgical margin =5 mm, moderate and poor differentiation, perineural invasion, vessel invasion, lymphovascular invasion, and tumor invasion depth = 10mm, age of 18 to 70 years of either sex, ECOG of 0 -1, adequate hematologic, renal, and hepatic function, adequate Creatinine clearance
Exclusion criteria
Exclusion criteria: Presence of positive resection margins, extra capsular spreading in metastatic nodes, history of previous cancer, second synchronous malignancy, any contraindication for concurrent chemotherapy and radiotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Loco-regional control at 3 months of treatmentTimepoint: 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Acute toxicity, overall Survival, disease free survival, late toxicity (after 3 months of completion of treatment) Timepoint: 3 months | — |
Countries
India
Contacts
Public ContactDr Himanshu Mishra
Institute of Medical science, Banarus Hindu University
Outcome results
None listed