Study comparing the effect of Vitamin C on adrenal suppression by using Etomidate as the Induction Agent

The effect of Vitamin C on adrenal suppression by using Etomidate as the Induction Agent-A Double Blinded Randomised Control Trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/069140

Enrollment

Registered

2024-06-18

Start date

Unknown

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: premedication with oral vitamin c 1000mg: Oral vitamin c 1000mg is used as intervention 20mins prior to etomidate induction Control Intervention1: premedication with oral orange placebo

Eligibility

Inclusion criteria

Inclusion criteria: American society of Anesthesiologists (ASA)1-2

Exclusion criteria

Exclusion criteria: Age below 18 patients on steroid cardiac disorders renal disorders endocrine disorders

Design outcomes

Primary

Measure	Time frame
To measure serum cortisol levelsTimepoint: To measure serum cortisol levels 3 hours after surgery	—

Secondary

Measure	Time frame
Monitor hemodynamic parameters including MAP & to measure levels of inflammatory mediators including CRP,ESRTimepoint: 30mins 1hour 4hours 8hours 12hours 16hours 20hours 24hours	—

Countries

India

Contacts

Public ContactMonisha Chrishaille M

Sri Ramachandra Institute of Higher Education and Research

vrajesh.kodali@gmail.com9962398266

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026