Health Condition 1: C719- Malignant neoplasm of brain, unspecified
Conditions
Interventions
Intervention1: Hippocampus sparing volumetric modulated arc therapy.: one group will receive radiotherapy treatment with Hippocampus sparing volumetric modulated arc therapy, dose of 54Gy-60Gy at 2Gy
Sponsors
Post Graduate Institute of Medical Education and Research PGIMER Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients with infiltrative lower grade gliomas (grade 2-3) who have undergone tumor removal or at least biopsy with histopathologic confirmation. 2.Cranial radiotherapy is clinically indicated to prevent recurrence due to presence of high risk features (astrocytoma histology), subtotal resection (STR) or age older than 40 years. 3.Karnofsky Performance Status Scale score (KPS) more than or equal to 60. 4.No prior history of radiation to the brain. 5.No contraindications to contrast enhanced computed tomography (CECT) and contrast enhanced magnetic resonance imaging (CEMRI). 6.Routine blood parameters (Complete blood count (CBC), liver function test (LFT), kidney function test (KFT)) within normal limits. 7.Willing to give consent for the study.
Exclusion criteria
Exclusion criteria: 1)Any non malignant known CNS disease that can cause neurocognitive dysfunction. 2)Pregnant and lactating women. 3)Prior long term chemotherapy. 4)Moderate or severe neurocognitive dysfunction prior to radiotherapy (MMSE less than or equal to 18)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in neurocognitive functionTimepoint: pre radiotherapy treatment post radiotherapy treatment 3 months after radiotherapy treatment 6 months after radiotherapy treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in Depression, Anxiety & Stress Scale - 21 Items (DASS-21).Timepoint: Before radiotherapy treatment after radiotherapy treatment 3 months after radiotherapy treatment. 6 months after radiotherapy treatment.;Change in Quality of lifeTimepoint: Before radiotherapy treatment after radiotherapy treatment 3 months after radiotherapy treatment. 6 months after radiotherapy treatment. | — |
Countries
India
Contacts
Public ContactDr Aditya Mehta
Post Graduate Institute of Medical Education and Research, (PGIMER), CHANDIGARH
Outcome results
None listed