Comparison of intravenous Ketamine and Dexmedetomidine on pain following breast surgery.

Comparative study of intraoperative intravenous Ketamine and Dexmedetomidine on post-operative analgesia after Modified Radical Mastectomy. - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/06/069024

Enrollment

Registered

2024-06-18

Start date

Unknown

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C50- Malignant neoplasm of breast

Interventions

Intervention1: Injection Dexmedetomidine: GROUP D – Will be given Intra venous Dexmedetomidine as a loading dose of 0.6microgm/kg over 10 minutes followed by maintenance infusion dose of 0.5microgm/kg

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients undergoing elective MRM surgery under General Anaesthesia. 2. Age Group 18 years to 60 year. 3. ASA Grade 1 or 2 physical state.

Exclusion criteria

Exclusion criteria: 1.Planned post operative mechanical ventilation. 2.Planned regional anaesthesia/analgesia. 3.Perioperative Gabapentin, Magnesium use. 4.Pregnancy or breastfeeding. 5.Allergy to study medications. 6.H/O psychiatric disorder and substance abuse. 7.Significant preoperative hepatic dysfunction 8.Patient’s refusal.

Design outcomes

Primary

Measure	Time frame
post-op pain (by VAS score).Timepoint: 1hour, 2hours, 3hours, 4hours, 6hours, 8hours, 12hours, 18hours and 24 hours postoperatively	—

Secondary

Measure	Time frame
sedation (by Ramsay sedation scale), postoperative nausea and/or vomitingTimepoint: 1hour, 2hours, 3hours, 4hours, 6hours, 8hours, 12hours, 18hours and 24 hours postoperatively	—

Countries

India

Contacts

Public ContactDr S K Mathur

Institute of Medical Sciences,BHU

skmathurbhu@gmail.com9450955143

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026